Also known as:
Penamox is one of the best forms of antibiotic available today. It is used to treat infections
caused by certain bacteria, including: infections of the ear, nose, and throat (pneumonia, bronchitis);
infections of the genitourinary tract; infections of the skin and skin structure; infections of the
lower respiratory tract; gonorrhea, acute uncomplicated (ano-genital and urethral infections) in male
Penamox is also used before some surgery or dental work to prevent infection. It is also used in
combination with other medications to eliminate H. pylori, a bacteria that causes ulcers.
Penamox may also be used for other purposes not listed here.
Penamox acts by inhibiting the synthesis of bacterial cell wall and stopping the growth of
Penamox is available in capsules.
Penamox is usually taken every 8 hours (three times a day). It can be taken with or without
The chewable tablets should be crushed or chewed thoroughly before they are swallowed. The tablets and
capsules should be swallowed whole and taken with a full glass of water.
Take Penamox exactly as directed. Do not take more or less Penamox or take it more often than
prescribed by your doctor. Do not stop taking Penamox without talking to your doctor. To clear up
your infection completely, continue taking Penamox for the full course of treatment even if you feel
better in a few days. Stopping Penamox too soon may cause bacteria to become resistant to
Adults: 1 g PO once daily or 500 mg PO twice daily for 10 days. The American Heart Association (AHA)
recommends extended-release Penamox as an alternative to penicillin V for rheumatic fever
Infants, Children, and Adolescents: 25 mg/kg/dose (Max: 500 mg/dose) PO twice daily for 10 days is
recommended by the Infectious Diseases Society of America (IDSA). Alternatively, 50 mg/kg/dose PO once
daily (Max: 1 g/dose) for 10 days is recommended by The American Heart Association (AHA) as an
alternative to penicillin V. For ear/nose/throat infections in general, the FDA-approved dosage is 20
mg/kg/day PO in divided doses every 8 hours (Max: 250 mg/dose) or 25 mg/kg/day PO in divided doses every
12 hours (Max: 500 mg/dose) for mild to moderate infections and 40 mg/kg/day PO in divided doses every 8
hours (Max: 500 mg/dose) or 45 mg/kg/day PO in divided doses every 12 hours (Max: 875 mg/dose) for
In case of overdosage, discontinue medication, treat symptomatically, and institute supportive
measures as required. If the overdosage is very recent and there is no contraindication, an attempt at
emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51
pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of
Penamox are not associated with significant clinical symptoms and do not require gastric emptying.
Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of
patients after overdosage with Penamox.
Crystalluria, in some cases leading to renal failure, has also been reported after Penamox
overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis
be maintained to reduce the risk of Penamox crystalluria.
Renal impairment appears to be reversible with cessation of drug administration. High blood levels may
occur more readily in patients with impaired renal function because of decreased renal clearance of
Penamox. Penamox may be removed from circulation by hemodialysis.
Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep bottle closed tightly. Throw away any unused medicine after the expiration date. Keep out of the reach of children.