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Azithromycin (Zithromax)
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Azithromycin

Azithromycin is a macrolide antibiotic of azalides group. Azithromycin inhibits RNA-dependent protein synthesis of sensitive microorganisms. It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Other names for this medication:
Azatril, Azenil, Azibiot, Azicip, Azifast, Azilide, Azimac, Azimax, Azimed, Azinix, Azithral, Azitro, Azitrocin, Azitrom, Azitromicina, Azitrox, Aziwok, Azomax, Aztrin, Azycyna, Azyth, Binozyt, Hemomycin, Koptin, Macrozit, Sumamed, Tritab, Tromix, Zertalin, Zibramax, Zimax, Zistic, Zithrin, Zithromax, Zithrox, Zitrocin, Zival, Zocin, Zomax, Zycin

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Also known as:  Zithromax.

Description

Azithromycinis available as both a generic and brand-name drug. Brand name(s): Zithromax. Generic drugs usually cost less than the brand-name version.

Azithromycinis used to treat infections caused by bacteria.

This drug comes as a tablet, suspension, and extended-release suspension you take by mouth. It also comes as eye drops, as well as an intravenous form given by healthcare provider.

Azithromycinis a prescription drug.

Azithromycinis used to treat certain infections caused by bacteria. It should not be used to treat infections caused by viruses, such as the common cold. Azithromycinmay be used in combination with other antibiotics when it’s used to treat mycobacterium avium complex infection.

Azithromycinworks by stopping bacteria from multiplying. This kills the bacteria and treats your infection.

Dosage

Use Azithromycin as directed by your doctor.

Take Azithromycin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Do not take an antacid that has aluminum or magnesium in it within 1 hour before or 2 hours after you take Azithromycin.

Azithromycin works best if it is taken at the same time each day.

To clear up your infection completely, use Azithromycin for the full course of treatment. Keep using it even if you feel better in a few days.

Ask your health care provider any questions you may have about how to use Azithromycin.

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an Azithromycin overdose may include nausea, vomiting, diarrhea, and stomach discomfort.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Azithromycin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You are allergic to any ingredient in Azithromycin, to other macrolide antibiotics (eg, erythromycin), or to ketolide antibiotics (eg, telithromycin).

You are taking dofetilide, nilotinib, pimozide, propafenone, or tetrabenazine.

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The review authors independently selected trials for inclusion and assessed methodological quality. We extracted and analysed relevant data separately. We resolved disagreements by consensus.

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MUC5AC synthesis was assayed using RT-PCR and ELISA. Phosphorylation of ERK1/2 was determined by western blotting.

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To assess the prevalence of dysglycemia (hypoglycemia or hyperglycemia) associated with oral levofloxacin and gatifloxacin therapy in an outpatient setting, and to determine the characteristics of patients who developed dysglycemia while receiving either fluoroquinolone.

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Comparison of the voriconazole Cmax day 14/day 7 ratio for the voriconazole + erythromycin group with that of the voriconazole + placebo group yielded a ratio of 107.7%[90% confidence interval (CI) 90.6, 128.0]; for the voriconazole + azithromycin group, the ratio was 117.5% (90% CI 98.8, 139.7). Comparison of the voriconazole AUCtau day 14/day 7 ratios of the voriconazole + erythromycin and voriconazole + azithromycin groups with that of the voriconazole + placebo group showed ratios of 101.2% (90% CI 89.1, 114.8) and 107.9% (90% CI 95.1, 122.4), respectively. For voriconazole tmax, the differences between the day 14-day 7 calculations for the voriconazole + erythromycin or the voriconazole + azithromycin groups and that of the voriconazole + placebo group were - 0.2 h (90% CI - 0.8, 0.3) and - 0.1 h (90% CI - 0.7, 0.5), respectively. None of these changes was considered clinically relevant. The study drugs were well tolerated by subjects in all groups; the most common study drug-related adverse events were visual disturbances, reported in all groups, and abdominal pain, present in the voriconazole + erythromycin group.

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To determine the effect on the international normalized ratio (INR) of adding azithromycin to patients receiving stable dosages of warfarin.

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Although adverse drug reactions (ADRs) are not uncommon, true allergic (i.e., immunologic) reactions are infrequent. Estimates are that only 10% of reported "penicillin (PCN)-allergic" patients have true allergic drug reactions. Most studies of PCN-related ADR have been conducted in adult populations and suggest that the majority of adult patients presenting with PCN allergy history can safely receive the drug. The goal of this study was to examine the outcome of provocative drug challenges to antibiotics in a pediatric population and correlate outcomes with predictive factors. Through chart review, we identified 96 pediatric patients with history of an ADR to antibiotics who underwent skin testing (ST) and/or graded challenges to PCN (n = 52), cephalosporins (n = 7), azithromycin (AZT; n = 24), or clindamycin (n = 4). Of these children with an ADR, 87 (90.6%) tolerated provocative drug challenges and 9 (9.4%) were instructed to continue drug avoidance because of positive ST or failed challenge. Eight of the nine patients continued drug avoidance due to positive PCN ST (n = 4) or ADR during drug PCN challenge (n = 4). All AZT and cephalosporin challenges had negative outcomes, and only one patient did not proceed with the clindamycin challenge after a positive ST. True "antibiotic allergy" denoted by positive ST or failed challenge in patients with a history of ADR occurred in <10% of children included in this study, suggesting that without such testing nearly 90% might be treated with alternative antibiotics unnecessarily.

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Information was obtained from comparative clinical trials, abstracts, conference proceedings, and review articles. Indexing terms included azithromycin, clarithromycin, dirithromycin, erythromycin, roxithromycin, and macrolide antibiotics.

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All 354 strains tested were resistant to ampicillin, chloramphenicol and tetracycline. Co-trimoxazole resistance was found in 92.2% of strains, and 0.8% of strains were resistant to nalidixic acid. All strains were susceptible to ceftriaxone, ciprofloxacin, ofloxacin, pivmecillinam, azithromycin, loracarbef and fosfomycin. Of the 29 laboratories surveyed, 18 (62.1%) were able to isolate and identify S. dysenteriae correctly, and 9 (32%) were able to serotype it further to S. dysenteriae type 1. Twenty-seven (93.1%) had appropriate culture media and 26 (89.7%) had antisera for Shigella identification.

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azithromycin dose chronic sinusitis 2015-12-26

This research has to evaluate effectiveness and tolerance of Azithromycin (Azyter, Thea), in injection as an antibiotic prophylaxis in patients suffering Levomax 750 Mg from age-related macular degeneration (AMD).

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Chronic inflammation of the airways is a central component in lung diseases and is frequently associated with bacterial infections. Monitoring Flagyl Gel Side Effects the pro-inflammatory capability of bacterial virulence factors in vivo is challenging and usually requires invasive methods.

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In northern Nigeria, trachoma is an important public health problem, but there are currently few population Sulfa Derm Review -based data on prevalence of disease and no formal trachoma control programs.

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Targeting of apicoplast replication and protein synthesis in the apicomplexan Toxoplasma gondii has conventionally been associated with the typical "delayed death" phenotype, characterized by the death of parasites only in the generation following drug intervention. We demonstrate that antibiotics like clindamycin, chloramphenicol, and tetracycline, inhibitors of prokaryotic protein synthesis, invoke the delayed death phenotype in Plasmodium falciparum, too, as evident from a specific reduction of apicoplast genome copy number. Interestingly, however, molecules like triclosan, cerulenin, fops, and NAS-91, inhibitors of the recently discovered fatty acid synthesis pathway, and succinyl acetone, an inhibitor of heme biosynthesis that operates in the apicoplast of the parasite, display rapid and striking parasiticidal effects. Our results draw a clear distinction between apicoplast functions per se and the apicoplast as the site of metabolic pathways, which are required for parasite survival, and thus subserve the development Noroxin 400 Mg Tablets of novel antimalarial therapy.

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Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of Novidat Tablet 500mg Price SP with azithromycin.

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Meningococci responsible for significant morbidity and mortality rates in children are found in the oropharynx and nasopharynx and communicated with droplets. In this study, the prevalence of nasopharyngeal Neisseria meningitidis carriage, serogroup distribution and antibiotic resistance were Roxithromycin 300 Mg Dosage determined among healthy children in Cankaya municipality of Ankara province. The study involved 1155 students aged 7-19 years. Systematic sampling method was used for sample selection. To isolate N. meningitidis, modified Thayer-Martin medium was used. The antibiotic susceptibilities of N. meningitidis isolates were determined by agar dilution method for penicillin, sulfadiazine, rifampicin, and azithromycin. N. meningitidis carriage prevalence was found as 10.4% with serogroup B being the most predominant (47.5%). The prevalence of N. meningitidis carriage was found to be closely associated with living conditions however, tonsillectomy, tonsillar hypertrophy, passive or active smoking did not affect the rate of carriage. Overcrowded life style, use of old-fashioned stoves for heating, and living in shanty housing were determined as risk factors increasing N. meningitidis carriage. None of the strains showed beta-lactamase activity, and five strains (4.2%) had decreased sensitivity to penicillin. The resistance against sulfadiazine was 54.4%, while it was 26.9% against azithromycin. No rifampicin-resistant strain were detected. It can be concluded that the prevalence of meningococcal carriage in this study was similar to that of other European countries. Rifampicin should be the first drug of choice both for the treatment of meningococcal carriers and for the prophylaxis of the subjects who had been in contact with patients with meningococcal infection.

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Attachment of Giardia lamblia trophozoites to enterocytes is essential for colonization of the small intestine and is considered Duomox 1000 Antibiotic Prospect a prerequisite for Giardia-induced enterocyte damage. Inhibition of attachment may therefore have therapeutic potential.

azithromycin dosage sinus infection 2016-02-08

We determined the prevalence of macrolide and fluoroquinolone resistance-associated mutations in Mycoplasma genitalium DNA specimens from men with Dosage Macrobid For Uti non-gonococcal urethritis (NGU) and analysed their effects on antibiotic treatments of M. genitalium infections.

azithromycin pregnancy drug class 2016-06-15

Case report. A 19 Purbac Cost -year-old man with a history of Stevens-Johnson syndrome and multiple corneal transplants developed white crystalline corneal infiltrates.

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Syphilis is a chronic, multi-stage infectious disease that is usually transmitted sexually by contact with an active lesion of a partner or congenitally from an infected pregnant woman to her fetus. Although syphilis is still endemic in many developing countries, it has re-emerged in several developed countries. The resurgence of syphilis is a major Derma Zinc Reviews concern to global public health, particularly since the lesions of early syphilis increase the risk of acquisition and transmission of infection with human immunodeficiency virus (HIV). Because there is no vaccine to prevent syphilis, control is mainly dependent on the identification and treatment of infected individuals and their contacts with penicillin G, the first-line drug for all stages of syphilis. The emergence of clinically significant azithromycin resistance in Treponema pallidum subsp. pallidum, the syphilis agent, has resulted in treatment failures, thus precluding the routine use of this second-line drug. Information is presented here on the diagnosis and recommended antibiotic treatment of syphilis and the challenge of macrolide-resistant T. pallidum.

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Using information gathered from a MEDLINE search of the English language literature from 1966 to 1994, employing the key words "cervicitis," "C. trachomatis," "erythromycin," "tetracycline," "doxycycline," "ofloxacin," and "azithromycin," we developed a decision analysis model specific for a nonpregnant woman with uncomplicated Chlamydia trachomatis cervicitis. Options in this model included an initially cured infection, a failed initial cure resulting in persistent cervicitis, or pelvic inflammatory disease treated either on an inpatient or outpatient basis. Probability estimates for each option were derived from previously published reports. A cost-effectiveness analysis was performed for three end points: cost per cure with initial therapy, cost per case of pelvic inflammatory disease averted, and cost per hospitalization averted. Sensitivity analyses were done by varying the cure rates for each antibiotic and the complication rates for failed therapy. The costs incurred for treatment were also varied.