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Azithral (Zithromax)
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Azithral

Generic Azithral is created by pharmacy specialists to struggle against dangerous infections (STD, pneumonia, bronchitis, lungs, throat or ears infections, skin infections, MAC). Target of Generic Azithral is to control, ward off and terminate bacteria.

Other names for this medication:
Azatril, Azenil, Azibiot, Azicip, Azifast, Azilide, Azimac, Azimax, Azimed, Azinix, Azithromycin, Azitro, Azitrocin, Azitrom, Azitromicina, Azitrox, Aziwok, Azomax, Aztrin, Azycyna, Azyth, Binozyt, Hemomycin, Koptin, Macrozit, Sumamed, Tritab, Tromix, Zertalin, Zibramax, Zimax, Zistic, Zithrin, Zithromax, Zithrox, Zitrocin, Zival, Zocin, Zomax, Zycin

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Biaxin, Chloromycetin, Cipro, Tetracycline, Omnicef

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Also known as:  Zithromax.

Description

Azithral is used to treat bacterial infections in many different parts of the body. It is also used to prevent Mycobacterium avium complex (MAC) disease in patients infected with the human immunodeficiency virus (HIV).

Azithral belongs to the class of drugs known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, Azithral will not work for colds, flu, or other virus infections. Azithral injection may be used for other problems as determined by your doctor.

Azithral is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Azithral is used in certain patients with the following medical condition: Trachoma (treatment).

Dosage

Use Azithral as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Azithral is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Azithral at home, a health care provider will teach you how to use it. Be sure you understand how to use Azithral. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use Azithral if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

o clear up your infection completely, use Azithral for the full course of treatment. Keep using it even if you feel better in a few days.

Ask your health care provider any questions you may have about how to use Azithral.

Overdose

If you overdose Azithral and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Azithral overdosage: discomfort feeling in stomach, diarrhea, retching, nausea.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Azithral are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take antacids that contain aluminum or magnesium within 2 hours of taking Azithral.

Before taking Azithral, tell your doctor if you are using any of the following drugs: nelfinavir (Viracept); digoxin (Lanoxin, Lanoxicaps); ergot medicine such as methysergide (Sansert), ergotamine (Ergostat, Medihaler, Cafergot, Ercaf, Wigraine), dihydroergotamine mesylate (D.H.E., Migranal Nasal Spray); triazolam (Halcion); carbamazepine (Carbatrol, Tegretol); cyclosporine (Neoral, Sandimmune); phenytoin (Dilantin); cholesterol-lowering medicines such as lovastatin (Mevacor), atorvastatin (Lipitor), or cerivastatin (Baycol); a calcium channel blocker such as diltiazem (Cartia XT, Diltiazem, Tiazac), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), verapamil (Calan, Covera-HS); HIV medicines such as indinavir (Crixivan), ritonavir (Norvir), saquinavir (Invirase); alprazolam (Xanax), diazepam (Valium), midazolam (Versed), triazolam (Halcion); theophylline (Theo-Dur, Theolair, Theochron); warfarin (Coumadin); pimozide (Orap); or another antibiotic, especially clarithromycin (Biaxin) or erythromycin (E-Mycin, E.E.S, Ery-Tab).

If you are using any of these drugs, you may not be able to use Azithral, or you may need dosage adjustments or special tests during treatment.

There are many other medicines that can interact with Azithral. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

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A recent pilot study noted clinical benefit of macrolide therapy in the management of six lung transplant recipients with bronchiolitis obliterans syndrome (BOS), a condition previously regarded as irreversible.

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The 6th International Conference on Macrolides, Azalides, Streptogramins, Oxazolidinones and Ketolides was held this year in Bologna, Italy, January 24­25, 2002. While oxazolidinones were featured in only one presentation, there were many presentations on the azalide azithromycin. There were also presentations on other macrolides (clarithromycin) and ketolides (telithromycin and ABT-773), and a few presentations on streptogramins. Several stimulating and well-attended workshops, as well as special symposia, made it an interesting and worthwhile meeting. (c) 2002 Prous Science. All rights reserved.

azithral antibiotic dosage

92 chronic periodontitis subjects were randomly assigned to receive SRP alone (N=23) or combined with 500 mg azithromycin per day for 3 days (N=25), 250 mg metronidazole tid for 14 days (N=24) or 20 mg doxycycline bid for 3 months (N=20). Gingival redness, bleeding on probing, suppuration, pocket depth and attachment level were measured at baseline and 3, 6 and 12 months post therapy. The significance of changes in clinical parameters within groups over time was sought using the Friedman test and among groups using ANCOVA or the Kruskal Wallis test.

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Further work characterizing COPD endotypes, including this neutrophilic endotype, will be important as we strive to understand the mechanistic roots of this disease in the hope of creating more effective therapies.

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Azalide antibiotics demonstrate pharmacokinetics distinct from all antibacterial agents in common use. Following oral absorption, conventional oral antibiotics diffuse through serum and interstitial compartments and are eliminated rapidly. A minimal to moderate degree of intracellular penetration may be observed. The pharmacokinetics of azithromycin, the first azalide, are characterized by a rapid and extensive movement of the drug from the serum into intracellular compartments. A dynamic equilibrium exists between the intracellular, interstitial, and serum compartments, with predominant flux into tissue sites. Azithromycin is concentrated to a high degree within phagocytes and transported by chemotactic mechanisms to the site of infection. High concentrations of azithromycin are found in pulmonary, genital, and lymphatic tissues. Azithromycin's serum levels decline in a polyphasic manner with a terminal half-life of approximately 60 hours. These kinetics allow azithromycin to be administered once daily. It is predicted that after drug administration for 5 days, therapeutic levels of azithromycin will be maintained at the tissue sites of infection for an additional 4-7 days. Consideration of the extravascular pharmacodynamics of azithromycin is necessary when making predictions regarding its therapeutic application.

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Clinical isolates of M. abscessus subsp. abscessus (n = 21), M. abscessus subsp. bolletii (n = 16), M. abscessus subsp. massiliense (n = 10) and M. chelonae (n = 22) were characterized regarding their erm(41) and rrl genotypes and subjected to drug susceptibility testing (DST) for clarithromycin and azithromycin. Microdilution DST was performed in cation-adjusted Mueller-Hinton broth (pH 7.4) with readings at days 3, 7 and 12 and with pre-incubation at subinhibitory macrolide concentrations for erm(41) induction. In addition, the influence of variations in pH and growth medium on DST results was examined.

azithral antibiotic

Sitafloxacin (STFX) is a newly developed quinolone that has robust antimicrobial activity against periodontopathic bacteria. We previously reported that oral administration of STFX during supportive periodontal therapy was as effective as conventional mechanical debridement under local anesthesia microbiologically and clinically for 3 months. The aim of the present study was to examine the short-term and long-term microbiological and clinical effects of systemic STFX and azithromycin (AZM) on active periodontal pockets during supportive periodontal therapy. Fifty-one patients receiving supportive periodontal therapy were randomly allocated to the STFX group (200 mg/day of STFX for 5 days) or the AZM group (500 mg/day of AZM for 3 days). The microbiological and clinical parameters were examined until 12 months after the systemic administration of each drug. The concentration of each drug in periodontal pockets and the antimicrobial susceptibility of clinical isolates were also analyzed. The proportions of red complex bacteria, i.e., Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, which are the representative periodontopathic bacteria, were significantly reduced at 1 month and remained lower at 12 months than those at baseline in both the STFX and AZM groups. Clinical parameters were significantly improved over the 12-month period in both groups. An increase in the MIC of AZM against clinical isolates was observed in the AZM group. These results indicate that monotherapy with systemic STFX and AZM might be an alternative treatment during supportive periodontal therapy in patients for whom invasive mechanical treatment is inappropriate. (This study has been registered with the University Hospital Medical Information Network-Clinical Trials Registry [UMIN-CTR] under registration number UMIN000007834.).

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The present study showed the prevalence of GAS among the asymptomatic school children in this location. The chronic carriers were treated with azithromycin for 3 days. A bacteriological cure was confirmed by doing throat swab cultures at intervals of one month and four months after the treatment. Identification of the GAS carriers and treating them, not only prevents them from developing non -suppurative complications, but they also prevent the spread of GAS to their family members and other children.

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Mycoplasma hominis is intrinsically resistant to 14- and 15-membered macrolides and to the ketolide telithromycin but is susceptible to josamycin, a 16-membered macrolide, and lincosamides. The aim of our study was to investigate the in vitro development of macrolide resistance in M. hominis and to study the impact of ribosomal mutations on MICs of various macrolides and related antibiotics.

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azithral gel 2017-09-05

The in-vitro activities of CP-99, 219, ciprofloxacin, pefloxacin, azithromycin and penicillin was tested against 114 Neisseria gonorrhoeae strains. The MIC90s were: 0.008 mg/L (MIC range 0.001-0.06 mg/L Erythromycin Gel Price Australia ) for CP-99, 219, 0.008 mg/L (MIC range 0.001-0.25 mg/L) for ciprofloxacin, 0.12 mg/L (MIC range 0.008-4 mg/L) for pefloxacin, 0.25 mg/L (MIC range 0.03-1 mg/L) for azithromycin and 16 mg/L (MIC range 0.015-16 mg/L) for penicillin. The activity of CP-99,219 against various N. gonorrhoeae isolates was comparable to ciprofloxacin.

azithral 250 mg dose 2017-07-04

In standard strains, the SI of meropenem, ceftazidime, amikacin and ciprofloxacin alone were >32, >32, 16 and 16. After adding EPI, the SI of four antibiotics were 16, 16, 16, 8 (reserpine), 16, 32, 16, 8 (omeprazole), 8, 16, 16, 8 (azithromycin), 8, 8, 16, 8 (CCCP) and 8, 16, 16, 8 (PAβN). The SI Levofloxacino 250 Mg of meropenem, ceftazidime and ciprofloxacin plus amikacin were 4, 4, 8. And the SI of amikacin plus ciprofloxacin was 4. In clinical strains, the SI of ciprofloxacin significantly decreased after adding CCCP.

azithral 500 dosage 2016-08-25

48 patients were randomised; (25 azithromycin, 23 placebo). It was established, post randomisation that two did not have BOS. 46 patients were analysed as intention to treat (ITT) with 33 'Completers'. ITT analysis included placebo patients treated with open-label azithromycin after Clamoxin 12 H Dosage study withdrawal.

azithral syrup dosage 2016-10-12

There were no statistically significant differences in antibiotic consumption with regulated or unregulated dispensing, either Azitromicina 700 Mg before or after the introduction of measures regulating the dispensing of antibiotics.

azithral tablet use 2016-09-01

Risk of travellers' diarrhoea is about 7% in developed countries and 20-50% in the developing world. Options for prevention include education and chemoprophylaxis. Vaccination is a promising but incomplete option. Achieving behaviour modification of food and water choices among tourists is difficult. Bismuth subsalicylate (BSS)-containing compounds are about 62% effective in the prevention of travellers' diarrhoea. Antibiotics are about 84% effective in preventing travellers' diarrhoea. Routine prophylaxis of travellers' diarrhoea, especially with antibiotics, should be discouraged. Oral rehydration is generally important in the treatment of diarrhoea, but travellers' diarrhoea is only infrequently dehydrating in adults. The addition of oral rehydration solutions confers no additional benefit to Obat Cefspan 100 Mg loperamide in the treatment of travellers' diarrhoea in adults. Presently, the most active of the antibiotics routinely available for treatment are members of the fluoroquinolone group. Antibiotics that are not absorbed such as aztreonam and a rifampicin-like agent, rifaximin, are both effective. The latter might become a therapy of choice once it is routinely available, due to predictably less adverse reactions with a non-absorbed antibiotic. Preliminary results with azithromycin look very promising. Less severe disease can be treated with a variety of non-antibiotic agents (e.g. BSS-containing compounds, loperamide and a calmodulin inhibitor, zaldaride). The combination of an antibiotic and loperamide is superior to treatment with either agent alone in a several studies and is arguably the treatment of choice for distressing travellers' diarrhoea.

azithral tab 2015-03-03

Gonorrhea is a major cause of serious reproductive complications in women and can facilitate human immunodeficiency virus (HIV) transmission. Effective treatment is a cornerstone of U.S. gonorrhea control efforts, but treatment of gonorrhea has been complicated by the ability of Neisseria gonorrhoeae to develop antimicrobial resistance. This report, using data from CDC's Gonococcal Isolate Surveillance Project (GISP), describes laboratory evidence of declining cefixime susceptibility among urethral N. gonorrhoeae isolates collected in the United States during 2006-2011 and updates CDC's current recommendations for treatment of gonorrhea. Based on GISP data, CDC recommends combination therapy with ceftriaxone 250 mg intramuscularly and either azithromycin 1 g orally as a single dose or doxycycline 100 mg orally twice daily for 7 days as the most reliably effective treatment for uncomplicated gonorrhea. CDC no longer recommends cefixime at any dose as a first-line regimen for treatment of gonococcal infections. If cefixime is used as an alternative agent, then the patient should return in 1 Mahacef Dry Syrup Dosage week for a test-of-cure at the site of infection.

azithral 500 mg use 2017-01-01

This study demonstrates Chloramphenicol 500 Mg Tablets that azithromycin suppresses P. gingivalis LPS-induced cytokine/chemokine protein production in HGF, which may explain some of the clinical benefits observed with the adjunctive use of azithromycin in the treatment of periodontitis.

azithral 500 mg acne 2015-09-21

The minimum inhibitory concentrations (MICs) of ten antibiotics were determined by the agar dilution method for 40 strains of penicillin-resistant Streptococcus pneumoniae, all of which were clinical Antirobe Tablets isolates from this laboratory. The antibiotics tested were clarithromycin, erythromycin, teicoplanin, vancomycin, ceftriaxone, cefodizime, azithromycin, ramoplanin, ciprofloxacin and MDL 62873. Of these agents, clarithromycin, vancomycin, teicoplanin, ceftriaxone, ramoplanin and MDL 62873 were the most active. The role of these antibiotics as alternatives to penicillin for the treatment of infections caused by penicillin-resistant S. pneumoniae is discussed.

azithral 500 tablet price 2016-07-20

In the context of a closed population receiving directly observed treatment for urogenital chlamydia infection, the efficacy of azithromycin was 97%, and the efficacy of doxycycline was 100%. Tab Tambac 200 Mg The noninferiority of azithromycin was not established in this setting. (Funded by the National Institute of Allergy and Infectious Diseases; ClinicalTrials.gov number, NCT00980148.).

azithral medicine side effects 2015-05-31

Using rpoB and hsp65, M. abscessus subsp. bolletii could be distinguished from M. abscessus subsp. abscessus. Amikacin and azithromycin showed excellent activity against M. abscessus in vitro. Imipenem, linezolid, cefoxitin, and moxifloxacin also showed good activity. Levofloxacin was inactive against M. abscessus. Although clarithromycin showed excellent activity against M. abscessus on day 3, inducible resistance occurred, Gimalxina Dosage 500mg and after 14 days clarithromycin showed little activity against M. abscessus subsp. abscessus, but still had good activity against M. abscessus subsp. bolletii.

azithral 250 dosage 2016-06-23

Eukaryotic pathogens of the phylum Apicomplexa contain a non-photosynthetic plastid, termed apicoplast. Within this organelle distinct iron-sulfur [Fe-S] cluster proteins are likely central to biosynthesis pathways, including generation of isoprenoids and lipoic acid. Here, we targeted a nuclear-encoded component of the apicoplast [Fe-S] cluster biosynthesis pathway by experimental genetics in the murine malaria parasite Plasmodium berghei. We show that ablation of the gene encoding a nitrogen fixation factor U (NifU)-like domain containing protein (NFUapi) resulted in parasites that were able to complete the Amoxicilina 250 Mg Bula entire life cycle indicating redundant or non-essential functions. nfu (-) parasites displayed reduced merosome formation in vitro, suggesting that apicoplast NFUapi plays an auxiliary role in establishing a blood stage infection. NFUapi fused to a combined fluorescent protein-epitope tag delineates the Plasmodium apicoplast and was tested to revisit inhibition of liver stage development by azithromycin and fosmidomycin. We show that the branched apicoplast signal is entirely abolished by azithromycin treatment, while fosmidomycin had no effect on apicoplast morphology. In conclusion, our experimental genetics analysis supports specialized and/or redundant role(s) for NFUapi in the [Fe-S] cluster biosynthesis pathway in the apicoplast of a malarial parasite.

azithral dose for child 2016-01-23

Two hundred fourteen children (90%) were present at 1-year follow-up with 10% dropout, and 178 (75%) were present at 3-year follow-up with 25% dropout. Of these, 23% and 11% had active trachoma at 1 and 3 years, respectively. Active trachoma was minimized from 100% at baseline to 11% at the end of 3 years. The reinfection rate was 4%. None of the patients developed trachoma-related ocular complications during the study period.